Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma.

  title={Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma.},
  author={Gad Singer and Robert J Oldt and Yoram Cohen and B. Gi-Nam Wang and David Sidransky and Robert J. Kurman and Ie-Ming Shih},
  journal={Journal of the National Cancer Institute},
  volume={95 6},
Activating mutations in KRAS and in one of its downstream mediators, BRAF, have been identified in a variety of human cancers. To determine the role of mutations in BRAF and KRAS in ovarian carcinoma, we analyzed both genes for three common mutations (at codon 599 of BRAF and codons 12 and 13 of KRAS). Mutations in either codon 599 of BRAF or codons 12 and 13 of KRAS occurred in 15 of 22 (68%) invasive micropapillary serous carcinomas (MPSCs; low-grade tumors) and in 31 of 51 (61%) serous… CONTINUE READING
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