Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

  title={Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans},
  author={D. Keays and G. Tian and K. Poirier and G. Huang and C. Siebold and J. Cleak and P. Oliver and M. Fray and R. Harvey and Z. Moln{\'a}r and M. Pi{\~n}on and N. Dear and W. Valdar and S. Brown and K. Davies and J. Rawlins and N. Cowan and P. Nolan and J. Chelly and J. Flint},
  pages={45 - 57}
  • D. Keays, G. Tian, +17 authors J. Flint
  • Published 2007
  • Biology, Medicine
  • Cell
  • Summary The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration. We show that the causative mutation… CONTINUE READING
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