Mutations galore in myeloproliferative neoplasms: Would the real Spartacus please stand up?

@article{Tefferi2011MutationsGI,
  title={Mutations galore in myeloproliferative neoplasms: Would the real Spartacus please stand up?},
  author={Ayalew Tefferi},
  journal={Leukemia},
  year={2011},
  volume={25},
  pages={1059-1063}
}
Current evidence supports the view that BCR-ABL1 is the disease-causing mutation in chronic myelogenous leukemia (CML): (i) it is invariably present in CML and absent in other chronic myeloid malignancies; (ii) it induces CML-like disease in mice; and (iii) anti-BCR-ABL1 targeted therapy in CML results in complete and durable hematologic, cytogenetic and molecular remissions. In an ongoing quest to identify BCR-ABL1-like mutations in other myeloproliferative neoplasms (MPNs), scientists have… CONTINUE READING