Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro.

@article{Zrcher2006MutationsCZ,
  title={Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro.},
  author={Thomas Z{\"u}rcher and Phillip James Yates and Janet M. Daly and Anjali Sahasrabudhe and Matthew T. Walters and Laura Dash and Margaret Tisdale and Jennifer L McKimm-Breschkin},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={58 4},
  pages={
          723-32
        }
}
BACKGROUND Viruses resistant to zanamivir have been generated in vitro, but no resistant virus has yet been isolated from a zanamivir-treated immunocompetent patient. In contrast most resistant viruses isolated from oseltamivir-treated patients correspond to those selected in vitro. However, despite mutations being in conserved residues in the neuraminidase (NA) they do not confer resistance in all NA subtypes. OBJECTIVES AND METHODS We have used reverse genetics and the recombinant… CONTINUE READING

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