Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

  title={Mutations and selection in the generation of class II histocompatibility antigen polymorphism.},
  author={Kenth Gustafsson and Klas G Wiman and Eva Emmoth and Dan Larhammar and Jan B{\"o}hme and Jens Jorgen Hyldig-Nielsen and Hans Ronne and Per A. Peterson and Lars Rask},
  journal={The EMBO Journal},
A comparison of seven human DR and DC class II histocompatibility antigen beta‐chain amino acid sequences indicates that the allelic variation is of comparable magnitude within the DR and DC beta‐chain genes. Silent and replacement nucleotide substitutions in six DR and DC beta‐chain sequences, as well as in seven murine class II sequences (three I‐A beta and four I‐A alpha alleles) were analyzed. The results suggest that the mutation rates are of a comparable magnitude in the nucleotide… Expand
Selection for Polymorphism in the Antigen Recognition Site of Major Histocompatibility Complex Class II Molecules
The results show that polymorphism is selected for in the antigen recognition site of class II molecules since replacement substitutions in this region were found to occur at a significantly higher frequency than expected in the absence of selection. Expand
Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens
The molecular revelations of the last few years have resolved many questions about the polymorphisms of Class II products, but many new questions need to be resolved before these molecules and their extensive polymorphism can be properly understood. Expand
Evolution of MHC Class II Allelic Diversity
The class I and class II molecules of the major histocompatibility complex are cell surface heterodimeric proteins whose primary function is the presentation of self and foreign antigens to T cells.Expand
Generation of Class II Antigen Polymorphism
Observed observations suggest that the low frequencies even of the most prevalent alleles in outbred populations render homozygosity at the MHC loci uncommon, and suggest that evolution has not grossly favored any single allele over the others. Expand
The evolution of allelic diversity at the primate major histocompatibility complex class II loci.
The highest number of phylogenetically inferred changes attributed to balancing selection was found at beta-chain residues located in the ABS and at those residues implicated in disease susceptibility, which supports the view that these positions are subject to some form of balancing selection. Expand
Genetic Complexity and Expression of Human Class II Histocompatibility Antigens
In addition to studies of expression by DNA-mediated gene transformation, a system for the gene transfer of MHC antigens utilizing transmissible retrovirus vectors is described and the control of expression of class II genes by gamma-interferon has been examined. Expand
Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR β loci
Sequence comparisons of four cDNA clones suggest that new coding sequences for DR β molecules in the DR2 haplotypes are potentially generated by reciprocal intergenic exchange. Expand
Cloning and sequence analysis of 14 DRB alleles of the bovine major histocompatibility complex by using the polymerase chain reaction.
The significantly higher frequency of replacement substitutions compared with the frequency of silent substitutions provides strong evidence that there is selection for genetic diversity in the bovine DRB3 first domain exon and a comparison of the DRB polymorphism in man and cattle reveals a striking similarity. Expand
DNA sequence analysis of a rat RT1 class 11 Aβ gene
Analysis of the nucleotide sequence encoding the two external domains suggests that the membrane proximal domain has been subject to conservative selection, whereas replacement substitutions have been selected positively at certain residues within the amino terminal domain. Expand
The nucleotide sequence and evolution of ovine MHC class II B genes: DQB and DRB
The Ovar-DRB gene identified in this study was found to be a pseudogene, lacking a defined exon 2 and containing premature termination codons in both exons 3 and 4. Expand


Comprehensive Immunogenetics
Thoroughly modern in perspective, this outstanding new text covers the entire field of immunogenetics. Emphasizing basic principles, problem solving and applications, it examines topics now a t theExpand
Comprehensive Immunogenetics, published by Elsevier/North Holland, NY
  • 1981
The Role of the Products of the Histocompatibility Gene Complex
  • 1976
The Role of the Products of the Histocompatibility Gene Complex in the Immune Response
  • 1976