Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

@article{Gustafsson1984MutationsAS,
  title={Mutations and selection in the generation of class II histocompatibility antigen polymorphism.},
  author={K. Gustafsson and K. Wiman and E. Emmoth and D. Larhammar and J. B{\"o}hme and J. J. Hyldig-Nielsen and H. Ronne and P. A. Peterson and L. Rask},
  journal={The EMBO Journal},
  year={1984},
  volume={3}
}
A comparison of seven human DR and DC class II histocompatibility antigen beta‐chain amino acid sequences indicates that the allelic variation is of comparable magnitude within the DR and DC beta‐chain genes. Silent and replacement nucleotide substitutions in six DR and DC beta‐chain sequences, as well as in seven murine class II sequences (three I‐A beta and four I‐A alpha alleles) were analyzed. The results suggest that the mutation rates are of a comparable magnitude in the nucleotide… Expand
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