Mutations and promoter methylation status of NPM1 in myeloproliferative disorders.

Abstract

We determined mutations and promoter methylation status of NPM1 using pyrosequencing in 199 samples of myeloid neoplasia including myeloproliferative disorders (MPD). The mutations were present in 4% of chronic myelomonocytic leukemia, but not in other MPD or myelodysplastic syndromes. Promoter methylation was rare, and was found in only three samples of… (More)

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Cite this paper

@article{Oki2006MutationsAP, title={Mutations and promoter methylation status of NPM1 in myeloproliferative disorders.}, author={Yasuhiro Oki and Jaroslav Jel{\'i}nek and Miloslav A. Beran and Srdan Verstovsek and Hagop M. Kantarjian and Jean-Pierre Issa}, journal={Haematologica}, year={2006}, volume={91 8}, pages={1147-8} }