Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.

@article{Lang2007MutationsAP,
  title={Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.},
  author={Carmen Lang and Yvonne Meier and Bruno Stieger and Ulrich H. W. Beuers and Thomas Bob Lang and Reinhold Kerb and Gerd A Kullak-Ublick and Peter Meier and Christiane Pauli-Magnus},
  journal={Pharmacogenetics and genomics},
  year={2007},
  volume={17 1},
  pages={47-60}
}
OBJECTIVES Increasing evidence suggests that a genetically determined functional impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the development of drug-induced liver injury. The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury and to in vitro functionally characterize newly… CONTINUE READING
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