Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms

@article{Brecqueville2011MutationsAD,
  title={Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms},
  author={M. Brecqueville and N. Cervera and J. Adélaı̈de and J. Rey and N. Carbuccia and M. Chaffanet and M. Mozziconacci and N. Vey and D. Birnbaum and V. Gelsi-Boyer and A. Murati},
  journal={Blood Cancer Journal},
  year={2011},
  volume={1}
}
Alterations of epigenetic marks have an important role in myeloid malignancies.1 Mutations have been found in several epigenetic regulators including ASXL1, DNMT3A, EZH2, IDH1/2 and TET2.2, 3 DNMT3A, IDH1/2 and TET2 are involved in the regulation of DNA methylation. EZH2 belongs to a complex of proteins called ‘polycomb repressor complex 2' (PRC2).4 ASXL1 is a regulator of PRC1, the other polycomb complex. Several other proteins belong to the two polycomb complexes; although alterations of… Expand
EZH2 in Myeloid Malignancies
Epigenetic alterations in hematopoietic malignancies
Disordered Epigenetic Regulation in the Pathophysiology of Myeloproliferative Neoplasms
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms
Double sword role of EZH2 in leukemia.
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