Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms

  title={Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms},
  author={Mandy Brecqueville and Nathalie Cervera and Jos{\'e} Ad{\'e}la{\"i}de and J{\'e}r{\^o}me Rey and Nadine Carbuccia and Max Chaffanet and M J Mozziconacci and Norbert Vey and David J. Birnbaum and V{\'e}ronique Gelsi-Boyer and Anne Murati},
  booktitle={Blood cancer journal},
Alterations of epigenetic marks have an important role in myeloid malignancies. Mutations have been found in several epigenetic regulators including ASXL1, DNMT3A, EZH2, IDH1/2 and TET2. DNMT3A, IDH1/2 and TET2 are involved in the regulation of DNA methylation. EZH2 belongs to a complex of proteins called ‘polycomb repressor complex 2’ (PRC2). ASXL1 is a regulator of PRC1, the other polycomb complex. Several other proteins belong to the two polycomb complexes; although alterations of ASXL1 and… CONTINUE READING


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