Mutations affecting the delayed rectifier potassium current in Drosophila.

  title={Mutations affecting the delayed rectifier potassium current in Drosophila.},
  author={Maninder Jit S. Chopra and G G Gu and Satpal Singh},
  journal={Journal of neurogenetics},
  volume={14 2},
Mutations and pharmacological agents have been used to resolve and analyze several K(+) currents in Drosophila. Mutations that affect channels carrying the voltage-activated I(A) and the Ca(2+) -activated I(CF) have helped greatly in analyzing the structure, function and regulation of these channels. We now report mutations that selectively affect the delayed rectifier current, I(K). Flies mutagenized with ethylmethanesulfonate were screened for temperature-induced paralysis. Paralytic mutants… CONTINUE READING

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