Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

@article{Borghese2012MutationsMA,
  title={Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.},
  author={Cecilia M Borghese and Wei Xiong and Seil Oh and Angel Ho and S John Mihic and Li Zhang and David M. Lovinger and Gregg E Homanics and Edmond I. Eger and R. Adron Harris},
  journal={Anesthesiology},
  year={2012},
  volume={117 4},
  pages={765-71}
}
BACKGROUND Volatile anesthetics (VAs) alter the function of key central nervous system proteins but it is not clear which, if any, of these targets mediates the immobility produced by VAs in the face of noxious stimulation. A leading candidate is the glycine receptor, a ligand-gated ion channel important for spinal physiology. VAs variously enhance such function, and blockade of spinal glycine receptors with strychnine affects the minimal alveolar concentration (an anesthetic EC50) in… CONTINUE READING