Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.

@article{Kiaris1995MutationsEA,
  title={Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.},
  author={Hippokratis Kiaris and Demetrios A. Spandidos and Alan S. Jones and Edwin Darracott Vaughan and John K. Field},
  journal={British Journal of Cancer},
  year={1995},
  volume={72},
  pages={123 - 128}
}
Mutation and overexpression are the main activating mechanisms for the ras family of genes in human cancer and the variable tandem repeat (VTR) located at the 3' end of H-ras has been associated with this risk. In the present study, we have analysed the relative levels of expression of H-ras mRNA in 26 samples of squamous cell carcinomas of the head and neck (SCCHN) by competitive reverse transcription-polymerase chain reaction (competitive RT-PCR) and also investigated whether there is an… CONTINUE READING

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