Mutational studies of the drug-resistance of M. tuberculosis with special reference to p-aminosalicylic acid, ethambutol, isoniazid and rifampicin.

In the M. tuberculosis H37Rv and in the human tubercular strains isolated from patients, the localization of genetic determinants of drug-resistance to antitubercular chemotherapeutic drugs in current use was studied. Data obtained through the treatment of the resistanct strains with acridine dyes and ethidium bromide, and the analysis of irreversible… CONTINUE READING