Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings.

@article{Ahronowitz2007MutationalSO,
  title={Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings.},
  author={Iris Ahronowitz and Winnie W Xin and Rosemary Kiely and Katherine Sims and Mia Maccollin and Fabio Pereira Nunes},
  journal={Human mutation},
  year={2007},
  volume={28 1},
  pages={1-12}
}
The NF2 tumor suppressor gene on chromosome 22 is a member of the protein 4.1 family of cytoskeletal elements. A number of single- and multiple-tumor phenotypes have been linked to alterations of NF2 since its characterization in 1993. We present a meta-analysis of 967 constitutional and somatic NF2 alterations from 93 published reports, along with 59… CONTINUE READING