Mutational specificity of ultraviolet light in Escherichia coli with and without the R plasmid pKM101.

@article{Fowler1981MutationalSO,
  title={Mutational specificity of ultraviolet light in Escherichia coli with and without the R plasmid pKM101.},
  author={Robert G. Fowler and Laura McGinty and Kristien E. Mortelmans},
  journal={Genetics},
  year={1981},
  volume={99 1},
  pages={25-40}
}
Plasmid pKM101 provides UV protection and increases the frequency of spontaneous and UV-induced mutations in Escherichia coli. By analyzing reversion patterns of defined trpA alleles, we showed that pKM101 altered the mutational specificity of UV-induced mutations. Certain UV-induced base-pair substitutions were strongly enhanced, while others were decreased in frequency in the presence of pKM101. This result suggests an interaction between cellular misrepair and an error-prone repair function… CONTINUE READING
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