Mutational signatures: the patterns of somatic mutations hidden in cancer genomes☆

@inproceedings{Alexandrov2014MutationalST,
  title={Mutational signatures: the patterns of somatic mutations hidden in cancer genomes☆},
  author={Ludmil B. Alexandrov and Michael R. Stratton},
  booktitle={Current opinion in genetics & development},
  year={2014}
}
All cancers originate from a single cell that starts to behave abnormally due to the acquired somatic mutations in its genome. Until recently, the knowledge of the mutational processes that cause these somatic mutations has been very limited. Recent advances in sequencing technologies and the development of novel mathematical approaches have allowed deciphering the patterns of somatic mutations caused by different mutational processes. Here, we summarize our current understanding of mutational… CONTINUE READING