Mutational profiles of Brenner tumors show distinctive features uncoupling urothelial carcinomas and ovarian carcinoma with transitional cell histology.

@article{Pfarr2017MutationalPO,
  title={Mutational profiles of Brenner tumors show distinctive features uncoupling urothelial carcinomas and ovarian carcinoma with transitional cell histology.},
  author={Nicole Pfarr and Silvia Darb-Esfahani and Jonas Leichsenring and Eliane Tabea Taube and Melanie Boxberg and Ioana Elena Braicu and Moritz Jesinghaus and Roland Penzel and Volker Endris and Aurelia Noske and Wilko Weichert and Peter Schirmacher and Carsten Denkert and Albrecht Stenzinger},
  journal={Genes, chromosomes & cancer},
  year={2017},
  volume={56 10},
  pages={
          758-766
        }
}
Brenner tumors (BT) are rare ovarian tumors encompassing benign, borderline, and malignant variants. While the histopathology of BTs and their clinical course is well described, little is known about the underlying genetic defects. We employed targeted next generation sequencing to analyze the mutational landscape in a cohort of 23 BT cases (17 benign, 2 borderline, and 4 malignant) and 3 ovarian carcinomas with transitional cell histology (TCC). Copy number variations (CNV) were validated by… CONTINUE READING