Mutational mapping of the catalytic activities of human tyrosinase.

  title={Mutational mapping of the catalytic activities of human tyrosinase.},
  author={Raj Kamal Tripathi and Vincent J. Hearing and Kazunori Urabe and Pilar Aroca and Richard A. Spritz},
  journal={The Journal of biological chemistry},
  volume={267 33},
Tyrosinase (EC is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxyphenylalanine (dopa) and the subsequent oxidation of dopa to dopaquinone. It has been proposed that tyrosinase is also able to oxidize 5,6-dihydroxyindole (DHI), a later product in the melanogenic pathway, to indole-5,6-quinone. Tyrosinase enzymatic activity is deficient in patients with classic type I… CONTINUE READING
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