Mutational landscape and in silico structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interaction

@article{NelsonSathi2020MutationalLA,
  title={Mutational landscape and in silico structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interaction},
  author={Shijulal Nelson-Sathi and PK Umasankar and Easwaran Sreekumar and Radeep Krishna Radhakrishnan Nair and Iype Joseph and Sai Ravi Chandra Nori and Jamiema Sara Philip and Roshny Prasad and K. S. Navyasree and Shikha Ramesh and Heera R. Pillai and Sanu Ghosh and TR Santosh Kumar and Madhavan Radhakrishna Pillai},
  journal={bioRxiv},
  year={2020}
}
Protein-protein interactions between virus and host are crucial for infection. SARS-CoV-2, the causative agent of COVID-19 pandemic is an RNA virus prone to mutations. Formation of a stable binding interface between the Spike (S) protein Receptor Binding Domain (RBD) of SARS-CoV-2 and Angiotensin-Converting Enzyme 2 (ACE2) of host actuates viral entry. Yet, how this binding interface evolves as virus acquires mutations during pandemic remains elusive. Here, using a high fidelity bioinformatics… Expand
2 Citations
A computational approach to evaluate the combined effect of SARS-CoV-2 RBD mutations and ACE2 receptor genetic variants on infectivity: The COVID-19 host-pathogen nexus
TLDR
It is inferred that it is important to consider both ACE2 variants and circulating SARS-CoV-2 RBD mutations to assess the stability of the virus-receptor association and evaluate infectivity. Expand
SARS-CoV-2 RBD mutations, ACE2 genetic polymorphism, and stability of the virus-receptor complex: The COVID-19 host-pathogen nexus.
TLDR
It is inferred that it is important to consider both ACE2 genetic variants and Sars-CoV-2 RBD mutations to assess the stability of the virus-receptor association and evaluate the infectivity of circulating SARS-Co V-2. Expand

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