Mutational landscape and clonal architecture in grade II and III gliomas

@article{Suzuki2015MutationalLA,
  title={Mutational landscape and clonal architecture in grade II and III gliomas},
  author={Hiromichi Suzuki and Kosuke Aoki and Kenichi Chiba and Yusuke Sato and Yusuke Shiozawa and Yuichi Shiraishi and Teppei Shimamura and Atsushi Niida and Kazuya Motomura and Fumiharu Ohka and Takashi Yamamoto and Kuniaki Tanahashi and Melissa Ranjit and Toshihiko Wakabayashi and Tetsuichi Yoshizato and Keisuke Kataoka and Kenichi Yoshida and Yasunobu Nagata and Aiko Sato-Otsubo and Hiroko Tanaka and Masashi Sanada and Yutaka Kondo and Hisakazu Nakamura and Masahiro Mizoguchi and Tatsuya Abe and Yoshihiro Muragaki and Reiko Watanabe and Ichiro Ito and Satoru Miyano and Atsushi Natsume and Seishi Ogawa},
  journal={Nature Genetics},
  year={2015},
  volume={47},
  pages={458-468}
}
Grade II and III gliomas are generally slowly progressing brain cancers, many of which eventually transform into more aggressive tumors. Despite recent findings of frequent mutations in IDH1 and other genes, knowledge about their pathogenesis is still incomplete. Here, combining two large sets of high-throughput sequencing data, we delineate the entire picture of genetic alterations and affected pathways in these glioma types, with sensitive detection of driver genes. Grade II and III gliomas… CONTINUE READING
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