Mutational interference and the progression of Muller's ratchet when mutations have a broad range of deleterious effects.

@article{Sderberg2007MutationalIA,
  title={Mutational interference and the progression of Muller's ratchet when mutations have a broad range of deleterious effects.},
  author={R Jonas S{\"o}derberg and Otto G. Berg},
  journal={Genetics},
  year={2007},
  volume={177 2},
  pages={971-86}
}
Deleterious mutations can accumulate in asexual haploid genomes through the process known as Muller's ratchet. This process has been described in the literature mostly for the case where all mutations are assumed to have the same effect on fitness. In the more realistic situation, deleterious mutations will affect fitness with a wide range of effects, from almost neutral to lethal. To elucidate the behavior of the ratchet in this more realistic case, simulations were carried out in a number of… CONTINUE READING
10 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…