Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.

@article{Ionov2000MutationalIO,
  title={Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.},
  author={Yurij Ionov and Hiroshi Yamamoto and Stanislaw Krajewski and John C. Reed and M. Herma Perucho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 20},
  pages={
          10872-7
        }
}
A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene family underlie the MMP, a landmark for hereditary nonpolyposis colorectal cancer. These tumors define a distinctive pathway for carcinogenesis because they display a particular spectrum of mutated cancer genes containing target repeats for mismatch repair deficiency. One such gene is BAX, a proapoptotic member of… CONTINUE READING

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Oncogene 18, 2139–2142

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