Mutational biosynthesis of a new antibiotic, streptomutin A, by an idiotroph of Streptomyces griseus.

@article{Nagaoka1975MutationalBO,
  title={Mutational biosynthesis of a new antibiotic, streptomutin A, by an idiotroph of Streptomyces griseus.},
  author={Kozo Nagaoka and Andarnold L. Demain},
  journal={The Journal of antibiotics},
  year={1975},
  volume={28 9},
  pages={
          627-35
        }
}
Microorganisms producing antibiotics have been genetically converted by earlier workers to mutants which cannot produce antibiotic without supplementation with a moiety of the antibiotic. These antibiotics include neomycin, kanamycin, paromomycin, butirosin, sisomicin, ribostamycin and novobiocin. Success has not been reported for organisms producing guanidinocyclitol antibiotics such as streptomycin. We mutagenized conidia of the streptomycin-producing Streptomyces griseus strain 7-455F3 with… 
Mutational biosynthesis by idiotrophs of Micromonospora purpurea. I. Conversion of aminocyclitols to new aminoglycoside antibiotics.
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Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor.
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TLDR
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Combimicins, new kanamycin derivatives bioconverted by some Micromonosporas.
Sir: Recently various new aminoglycoside derivatives were obtained by a technique called "mutational biosynthesis" or "mutasynthesis".1~3) However, most of them were derivatives which could be
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A mutant of Micromonospora purpurea, which produces the gentamicin complex only when 2-deoxystreptamine is added to the fermentation medium , produces a new antibiotic complex, 2-hydroxygentamicin,
Mutational biosynthesis of butirosin analogs.
TLDR
These antibiotics were characterized and elucidated as 3', 4'-dideoxy-6'-N-methylbutirosins A and B (DMB-A & DMB-B), by chemical and spectroscopic studies, and exhibited stronger activities against butirosin-resistant organisms which contain acetylating enzymes AAC( 6')-I and AAC(6')-IV, and phosphorylating enzyme APH(3')-II.
Candicidin biosynthesis in Streptomyces griseus
TLDR
The modular architecture of the candicidin PKS and the availability of the PKSs involved in the biosynthesis of three polyene antibiotics shall make possible the creation of new, less toxic and more active polyenes antibiotics through combinatorial biosynthesis and targeted mutagenesis.
Isolation of streptomycin-nonproducing mutants deficient in biosynthesis of the streptidine moiety or linkage between streptidine 6-phosphate and dihydrostreptose
TLDR
This finding suggests that aminotransferase activity might have been negatively controlled by the end product, streptidine 6-phosphate, of the strePTidine biosynthetic pathway.
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