Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence

@article{Rubinsztein1994MutationalBP,
  title={Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence},
  author={David C Rubinsztein and William Amos and Jayne Leggo and Sandy F. Goodburn and Rajkumar Sewcharan Ramesar and John A. Old and Ronald Bontrop and Robert R. McMahon and David E Barton and M. A. Ferguson-Smith},
  journal={Nature Genetics},
  year={1994},
  volume={7},
  pages={525-530}
}
Huntington's disease (HD) correlates with abnormal expansion in a block of CAG repeats in the Huntington's disease gene. We have investigated HD evolution by typing CAG alleles in several human populations and in a variety of primates. We find that human alleles have expanded from a shorter ancestral state and exhibit unusual asymmetric length distributions. Computer simulations are used to show that the human state can be derived readily from a primate ancestor, without the need to invoke… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 54 CITATIONS

Similar Papers

Loading similar papers…