Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions

@article{Majores2005MutationalAI,
  title={Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions},
  author={Michael Majores and Volker Schick and Gudrun Engels and Jana Fassunke and Christian Erich Elger and Johannes Schramm and Ingmar Bl{\"u}mcke and Albert J. Becker},
  journal={Acta Neuropathologica},
  year={2005},
  volume={110},
  pages={537-546}
}
Glioneuronal lesions are frequently observed in biopsy specimens obtained from patients with pharmacoresistant epilepsies, comprising focal cortical dysplasias (FCD) and gangliogliomas. Recent findings point to the phosphoinositide 3-kinase (PI3K) pathway and tuberin/hamartin signaling cascade as being compromised in these lesions. Ezrin, radixin and moesin (ERM-/band-4.1 proteins) genes represent downstream effectors of the PI3K pathway, are involved in cytoskeleton-membrane interference, cell… CONTINUE READING

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