Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.

@article{Wei2010MutationalAF,
  title={Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.},
  author={Xiaomu Wei and Todd D. Prickett and Cristina Guti{\'e}rrez Viloria and Alfredo A Molinolo and Jimmy Cheng-Ho Lin and Isabel Cardenas-Navia and Pedro M. Rodr{\'i}guez Cruz and Steven A Rosenberg and Michael A. Davies and Jeffrey E Gershenwald and Carlos L{\'o}pez-Ot{\'i}n and Yardena Samuels},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 11},
  pages={1513-25}
}
The disintegrin-metalloproteinases with thrombospondin domains (ADAMTS) genes have been suggested to function as tumor suppressors as several have been found to be epigenetically silenced in various cancers. We performed a mutational analysis of the ADAMTS gene family in human melanoma and identified a large fraction of melanomas to harbor somatic mutations. To evaluate the functional consequences of the most commonly mutated gene, ADAMTS18, six of its mutations were biologically examined… CONTINUE READING