Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions.

@article{Schick2007MutationalAE,
  title={Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions.},
  author={Volker Schick and Michael Majores and Jana Fassunke and Gudrun Engels and Matthias Simon and Christian Erich Elger and Albert J. Becker},
  journal={Neuropathology and applied neurobiology},
  year={2007},
  volume={33 2},
  pages={152-62}
}
Gangliogliomas and focal cortical dysplasias (FCDs) constitute glioneuronal lesions, which are frequently encountered in biopsy specimens of patients with pharmacoresistant focal epilepsy and relate to impaired differentiation and migration of neural precursors. However, their molecular pathogenesis and relationship are still largely enigmatic. Recent data suggest several components of the insulin-pathway, including TSC1 and TSC2 mutated in tuberous sclerosis complex (TSC), to be altered in… CONTINUE READING