Mutational analysis of the zippering reaction during flavivirus membrane fusion.

@article{Pangerl2011MutationalAO,
  title={Mutational analysis of the zippering reaction during flavivirus membrane fusion.},
  author={Karen Pangerl and Franz X Heinz and Karin Stiasny},
  journal={Journal of virology},
  year={2011},
  volume={85 17},
  pages={8495-501}
}
The current model of flavivirus membrane fusion is based on atomic structures of truncated forms of the viral fusion protein E in its dimeric prefusion and trimeric postfusion conformations. These structures lack the two transmembrane domains (TMDs) of E as well as the so-called stem, believed to be involved in an intra- and intermolecular zippering reaction within the E trimer during the fusion process. In order to gain experimental evidence for the functional role of the stem in flavivirus… CONTINUE READING

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