Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.

@article{Sommer2001MutationalAO,
  title={Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.},
  author={Marvin H Sommer and Edward William Zagha and Oscar K Serrano and Chun Ching Ku and Leigh Zerboni and Armin Baiker and Renata Santos and Marianne Spengler and J. Lynch and Charles Grose and William T. Ruyechan and John Hay and Ann Margaret Arvin},
  journal={Journal of virology},
  year={2001},
  volume={75 17},
  pages={8224-39}
}
Varicella-zoster virus (VZV) open reading frame 63 (ORF63), located between nucleotides 110581 and 111417 in the internal repeat region, encodes a nuclear phosphoprotein which is homologous to herpes simplex virus type 1 (HSV-1) ICP22 and is duplicated in the terminal repeat region as ORF70 (nucleotides 118480 to 119316). We evaluated the role of ORFs 63 and 70 in VZV replication, using recombinant VZV cosmids and PCR-based mutagenesis to make single and dual deletions of these ORFs. VZV was… CONTINUE READING