Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for DNA binding and multimerization.

@article{Kullik1995MutationalAO,
  title={Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for DNA binding and multimerization.},
  author={Ines Kullik and James Stevens and Michel B. Toledano and Gisela Storz},
  journal={Journal of bacteriology},
  year={1995},
  volume={177 5},
  pages={1285-91}
}
OxyR is a LysR-type transcriptional regulator which negatively regulates its own expression and positively regulates the expression of proteins important for the defense against hydrogen peroxide in Escherichia coli and Salmonella typhimurium. Using random mutagenesis, we isolated six nonrepressing OxyR mutants that were impaired in DNA binding. Five of the mutations causing the DNA binding defect mapped near the N-terminal helix-turn-helix motif conserved among the LysR family members… CONTINUE READING

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