Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation.

@article{Farrar2010MutationalAO,
  title={Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation.},
  author={Dawn Farrar and Sushma Rai and Igor Chernukhin and Maja Jagodic and Yoko Ito and Samer Yammine and Rolf Ohlsson and Adele Murrell and Elena M. Klenova},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 5},
  pages={1199-216}
}
Poly(ADP-ribosyl)ation of the conserved multifunctional transcription factor CTCF was previously identified as important to maintain CTCF insulator and chromatin barrier functions. However, the molecular mechanism of this regulation and also the necessity of this modification for other CTCF functions remain unknown. In this study, we identified potential sites of poly(ADP-ribosyl)ation within the N-terminal domain of CTCF and generated a mutant deficient in poly(ADP-ribosyl)ation. Using this… CONTINUE READING

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Analysis of the vertebrate insulator protein CTCF - binding sites in the human genome

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