Mutational analysis of the mouse mitochondrial cytochrome b gene.

  title={Mutational analysis of the mouse mitochondrial cytochrome b gene.},
  author={Neil Howell and K. C. Gilbert},
  journal={Journal of molecular biology},
  volume={203 3},
The protonmotive cytochrome b protein of the mitochondrial bc1 respiratory chain complex contains two reactions centers, designated Qo and Qi, which can be distinguished by the effects of different inhibitors. The nucleotide sequences have been determined of the mitochondrial cytochrome b genes from a series of mouse cell mutants selected for increased inhibitor resistance. Each mutant contains a single nucleotide change which results in an amino acid substitution. When the proximity of the… CONTINUE READING