Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements.

@article{Minsavage2003MutationalAO,
  title={Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements.},
  author={Gary D Minsavage and Daria P Vorojeikina and Thomas A Gasiewicz},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={412 1},
  pages={95-105}
}
Tyrosine phosphorylation of the aryl hydrocarbon receptor (AhR), a member of the basic helix-loop-helix/PER-ARNT-SIM transcription factor family, has been shown to regulate its dioxin response elements (DRE) binding ability, although no specific residues have been directly demonstrated to be phosphorylated. Of the 23 tyrosines in the mouse AhR, 19 are conserved across all mammalian species sequenced thus far. The studies presented here were conducted to examine tyrosine residue(s) that are both… CONTINUE READING

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