Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis.

@article{StrambioDeCastillia1992MutationalAO,
  title={Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis.},
  author={Caterina Strambio-De-Castillia and Eric Hunter},
  journal={Journal of virology},
  year={1992},
  volume={66 12},
  pages={
          7021-32
        }
}
The major capsid (CA) protein of retroviruses possesses a stretch of 20 amino acids, called the major homology region (MHR), which is evolutionarily conserved and invariant in location within the primary sequence of the protein. The function of this region was investigated by examining the effect of random single-amino-acid substitutions within the central 13 positions of the MHR on the life cycle of Mason-Pfizer monkey virus (M-PMV), an immunosuppressive D-type retrovirus. When these mutants… CONTINUE READING

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