Mutational analysis of the leucine zipper motif in the Newcastle disease virus fusion protein.

@article{Reitter1995MutationalAO,
  title={Mutational analysis of the leucine zipper motif in the Newcastle disease virus fusion protein.},
  author={Julie N. Reitter and Theresa A. Sergel and Trudy G. Morrison},
  journal={Journal of virology},
  year={1995},
  volume={69 10},
  pages={
          5995-6004
        }
}
The paramyxovirus fusion proteins have a highly conserved leucine zipper motif immediately upstream from the transmembrane domain of the F1 subunit (R. Buckland and F. Wild, Nature [London] 338:547, 1989). To determine the role of the conserved leucines in the oligomeric structure and biological activity of the Newcastle disease virus (NDV) fusion protein, the heptadic leucines at amino acids 481, 488, and 495 were changed individually and in combination to an alanine residue. While single… CONTINUE READING

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