Mutational analysis of the hepatitis C virus RNA helicase.

  title={Mutational analysis of the hepatitis C virus RNA helicase.},
  author={D W Kim and Jinhyeong Kim and Yousang Gwack and Jang H. Han and Joonho Choe},
  journal={Journal of virology},
  volume={71 12},
The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of individual amino acid residues in the four conserved motifs (AXXXXGKS, DECH, TAT, and QRRGRTGR) of the NS3 protein, mutational analysis was used in this study. Thirteen mutant… CONTINUE READING


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