Mutational analysis of the disulfide catalysts DsbA and DsbB.

@article{Tan2005MutationalAO,
  title={Mutational analysis of the disulfide catalysts DsbA and DsbB.},
  author={Jacqueline Teng Teng Tan and Ying Lu and James C. A. Bardwell},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 4},
  pages={
          1504-10
        }
}
In prokaryotes, disulfides are generated by the DsbA-DsbB system. DsbB functions to generate disulfides by quinone reduction. These disulfides are passed to the DsbA protein and then to folding proteins. To investigate the DsbA-DsbB catalytic system, we performed an in vivo selection for chromosomal dsbA and dsbB mutants. We rediscovered many residues previously shown to be important for the activity of these proteins. In addition, we obtained one novel DsbA mutant (M153R) and four novel DsbB… CONTINUE READING

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