Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.

@article{Hauber1989MutationalAO,
  title={Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.},
  author={Joachim Hauber and Michael H Malim and Bryan R Cullen},
  journal={Journal of virology},
  year={1989},
  volume={63 3},
  pages={1181-7}
}
The tat trans-activators encoded by the known strains of primate immunodeficiency virus share a conserved, highly basic protein domain. Mutagenesis of this sequence in the tat gene of human immunodeficiency virus type 1 is shown here to reduce, but not eliminate, the trans-activation of human immunodeficiency virus type 1-specific gene expression. The degree of inhibition is shown to vary in a dose-dependent manner and is most marked at low levels of tat expression. Multiple mutations of the… CONTINUE READING

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