Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor.

@article{Proulx2008MutationalAO,
  title={Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor.},
  author={Christophe D Proulx and Brian J Holleran and Antony A. Boucard and Emanuel Escher and Ga{\'e}tan Guillemette and Richard Leduc},
  journal={Molecular pharmacology},
  year={2008},
  volume={74 3},
  pages={552-61}
}
Class A (rhodopsin-like) G protein-coupled receptors possess conserved residues and motifs that are important for their specific activity. In the present study, we examined the role of residue Asp97(2.50) as well as residues Glu147(3.49), Arg148(3.50), and Tyr149(3.51) of the ERY motif on the functionality of the urotensin II receptor (UT). Mutations D97(2.50)A, R148(3.50)A, and R148(3.50)H abolished the ability of UT to activate phospholipase C, whereas mutations E147(3.49)A and Y149(3.51)A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…