Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA.

@article{Paillart1994MutationalAO,
  title={Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA.},
  author={Jean-Christophe Paillart and Roland Marquet and Eugene Skripkin and Bernard Ehresmann and Chantal Ehresmann},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 44},
  pages={27486-93}
}
The genome of all retroviruses consists in two homologous RNA molecules associated near their 5' end in a region called the dimer linkage structure. Dimerization of genomic RNA is thought to be important for several functions of the retroviral cycle such as encapsidation, reverse transcription, and translation. In human immunodeficiency virus type 1 (HIV-1), a region downstream of the splice donor site was initially postulated to mediate dimerization. However, we recently showed that the… CONTINUE READING