Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas.

Abstract

Alterations in genes involved in cell cycle regulation are common in many tumor types. In pancreatic adenocarcinomas, inactivating mutations in the CDKN2 gene, encoding the cyclin-dependent kinase inhibitor p16, are frequently observed. CDKN2 mutations have also been identified in the germline of 50% of patients with hereditary melanoma. Interestingly, such… (More)

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Cite this paper

@article{Ceha1998MutationalAO, title={Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas.}, author={Heleen M. Ceha and Marie Cl{\'e}ment and Michel Polak and George Johan Arnold Offerhaus and Robbert J. C. Slebos}, journal={Pancreas}, year={1998}, volume={17 1}, pages={85-8} }