Mutational analysis of the P1 phosphorylation domain in Escherichia coli CheA, the signaling kinase for chemotaxis.

@article{Nishiyama2014MutationalAO,
  title={Mutational analysis of the P1 phosphorylation domain in Escherichia coli CheA, the signaling kinase for chemotaxis.},
  author={So-ichiro Nishiyama and Andr{\'e}s Garz{\'o}n and J. S. Parkinson},
  journal={Journal of bacteriology},
  year={2014},
  volume={196 2},
  pages={257-64}
}
The histidine autokinase CheA functions as the central processing unit in the Escherichia coli chemotaxis signaling machinery. CheA receives autophosphorylation control inputs from chemoreceptors and in turn regulates the flux of signaling phosphates to the CheY and CheB response regulator proteins. Phospho-CheY changes the direction of flagellar rotation; phospho-CheB covalently modifies receptor molecules during sensory adaptation. The CheA phosphorylation site, His-48, lies in the N-terminal… CONTINUE READING