Mutational analysis of the N-terminus of Moloney murine leukemia virus integrase.

@article{Yang2001MutationalAO,
  title={Mutational analysis of the N-terminus of Moloney murine leukemia virus integrase.},
  author={Fan Yang and Jennifer A Seamon and Monica J Roth},
  journal={Virology},
  year={2001},
  volume={291 1},
  pages={32-45}
}
The retroviral integrase (IN) carries out the integration of viral DNA into the host genome. The IN protein consists of three domains: the N-terminal HHCC motif, the catalytic core region, and the C-terminus. The Moloney murine leukemia virus (M-MuLV) IN encodes a unique 45-amino-acid domain N-terminal to the HHCC motif. The function of the N-terminus of M… CONTINUE READING