Mutational analysis of the GDNF/RET-GDNFRα signaling complex in a kindred with vesicoureteral reflux

@article{Shefelbine1998MutationalAO,
  title={Mutational analysis of the GDNF/RET-GDNFR$\alpha$ signaling complex in a kindred with vesicoureteral reflux},
  author={Sarah Elizabeth Shefelbine and Sangeeta Khorana and Pamela N. Schultz and Eileen Huang and Nicole Thobe and Zheng Hu and Gary M. Fox and Shuqian Jing and Gilbert J Cote and Robert F. Gagel},
  journal={Human Genetics},
  year={1998},
  volume={102},
  pages={474-478}
}
Glial cell line-derived neurotrophic factor (GDNF) mediates signaling across the cell membrane by interaction with the RET-GDNFRα receptor complex. We identified a family in which one member had medullary thyroid carcinoma (MTC) and four members had vesicoureteral reflux (VUR). Knowledge that mutations in the RET proto-oncogene cause MTC and studies documenting genitourinary abnormalities in RET or GDNF knockout mice led us to examine the GDNF/RET-GDNFRα signaling complex in this family. RET… 
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TLDR
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TLDR
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TLDR
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