Mutational analysis of the Cu/Zn superoxide dismutase gene in 23 familial and 69 sporadic cases of amyotrophic lateral sclerosis in Belgium

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder caused by degeneration of motor neurons of the spinal cord and brain. The majority of ALS cases are sporadic (SALS). However, in 10–15% of ALS cases the disease is inherited as an autosomal dominant trait (familial ALS or FALS). We used a non-radioactive SSCP method, in… (More)
DOI: 10.1038/sj.ejhg.5200337

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@article{Aguirre1999MutationalAO, title={Mutational analysis of the Cu/Zn superoxide dismutase gene in 23 familial and 69 sporadic cases of amyotrophic lateral sclerosis in Belgium}, author={Tania Aguirre and Gert Matthijs and Wim Robberecht and Petra Tilkin and J Cassiman}, journal={European Journal of Human Genetics}, year={1999}, volume={7}, pages={599-602} }