Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas.

@article{Uchida1995MutationalAO,
  title={Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas.},
  author={Toshikazu Uchida and Toshihide Watanabe and Taroh Kinoshita and Takashi Murate and Hidetane Saito and Tomomitsu Hotta},
  journal={Blood},
  year={1995},
  volume={86 7},
  pages={
          2724-31
        }
}
The CDKN2 gene located on chromosome 9p21 encodes the cyclin-dependent kinase-4 inhibitor p16. This gene is a putative tumor-suppressor gene because of its frequent alterations in many kinds of tumor cell lines. We analyzed the CDKN2 gene to evaluate its alterations in 52 primary specimens of non-Hodgkin's lymphoma (NHL) or chronic lymphocytic leukemia (CLL) of B-cell origin by Southern blot analysis, polymerase chain reaction-mediated single-strand conformation polymorphism (PCR-SSCP) analysis… CONTINUE READING
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