Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.

@article{Oleary1992MutationalAO,
  title={Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.},
  author={Michael E O'leary and Michael M. White},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 12},
  pages={8360-5}
}
A number of studies have demonstrated that a major portion of the ligand binding site of the Torpedo nicotinic acetylcholine receptor is near cysteines 192 and 193 of the alpha subunit. The role of conserved tyrosine and aspartate residues within this region in ligand binding and receptor activation was investigated using a combination of site-directed mutagenesis and expression in Xenopus oocytes. Wild-type receptors are half-maximally activated (K1/2) by 20 microM acetylcholine with a Hill… CONTINUE READING
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