Mutational analysis of human prothymosin alpha reveals a bipartite nuclear localization signal.

@article{Rubtsov1997MutationalAO,
  title={Mutational analysis of human prothymosin alpha reveals a bipartite nuclear localization signal.},
  author={Yuri P Rubtsov and Andrei S. Zolotukhin and Ivan A. Vorobjev and Nina V. Chichkova and Nikolai A Pavlov and E. M. Karger and Alexandra G Evstafieva and Barbara K Felber and Andrey B. Vartapetian},
  journal={FEBS letters},
  year={1997},
  volume={413 1},
  pages={135-41}
}
Mutants of human prothymosin alpha with impaired ability to inhibit yeast Saccharomyces cerevisiae. cerevisiae cell growth were characterized. Two types of prothymosin alpha-inactivating mutations were observed. Mutations that belong to the first type compromised the nuclear entry of prothymosin alpha by affecting its nuclear localization signal. Analysis of subcellular distribution of GFP-prothymosin alpha fusions revealed a bipartite nuclear localization signal that is both necessary and… CONTINUE READING

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