Mutational analysis of human papillomavirus type 16 E7 functions.

@article{Watanabe1990MutationalAO,
  title={Mutational analysis of human papillomavirus type 16 E7 functions.},
  author={Shoko Watanabe and Teru Kanda and Hironori Sato and Akira Furuno and Kunito Yoshiike},
  journal={Journal of virology},
  year={1990},
  volume={64 1},
  pages={
          207-14
        }
}
The human papillomavirus type 16 E7 gene encodes a nuclear oncoprotein (98 amino acids [AAs] long) consisting of three regions: regions 1 (AAs 1 to 20) and 2 (AAs 21 to 40), which show high homology to the sequences of conserved domains 1 and 2, respectively, of adenovirus E1A; and region 3 (AAs 41 to 98) containing two metal-binding motifs Cys-X-X-Cys (AAs 58 and 91 to 94). We constructed AA deletion (substitution) mutants and single-AA substitution mutants of E7 placed under the control of… CONTINUE READING

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