Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation.

@article{Zurek2012MutationalAO,
  title={Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation.},
  author={Birte Zurek and Martina Proell and Roland N. Wagner and Robert Schwarzenbacher and Thomas A Kufer},
  journal={Innate immunity},
  year={2012},
  volume={18 1},
  pages={100-11}
}
Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 are intracellular pattern recognition receptors (PRRs) of the nucleotide-binding domain and leucine-rich repeat containing (NLR) gene family involved in innate immune responses. Their centrally located NACHT domain displays ATPase activity and is necessary for activation and oligomerization leading to inflammatory signaling responses. Mutations affecting key residues of the ATPase domain of NOD2 are linked to severe… CONTINUE READING

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