Mutational analysis of gap junction formation.

  title={Mutational analysis of gap junction formation.},
  author={Gerhard P. Dahl and Ralf Werner and Elisheva Levine and C Rabadan-Diehl},
  journal={Biophysical journal},
  volume={62 1},
  pages={172-80; discussion 180-2}
The paired oocyte cell-cell channel assay was used to investigate the mechanisms involved in the process of formation of gap junction channels. Single oocytes, injected with connexin-specific mRNAs, accumulate a pool of precursors from which cell-cell channels can form rapidly upon pairing. Several lines of evidence, including immunohistochemistry and surface labeling, indicate that part of this precursor pool is located in the cell membrane, probably in the form of closed hemichannels. The… CONTINUE READING

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